CAPICE (Childhood and Adolescence Psychopathology: unravelling the complex etiology by a large Interdisciplinary Collaboration in Europe), is a project funded by the European Commission under the HORIZON 2020 Research and Innovation programme, Marie Skłodowska Curie Actions – MSCA-ITN-2016 – Innovative Training Networks.

In the Roadmap for Mental Health and Wellbeing Research in Europe (ROAMER), top-priority is research into child and adolescent mental health symptoms. CAPICE  will address this priority.

This network will elaborate on the EArly Genetics and Lifecourse Epidemiology (EAGLE) consortium, a well-established collaboration of the many European birth and adolescent population based (twin and family) cohorts with unique longitudinal information on lifestyle, family environment, health, and emotional and behavioral problems.

Phenotypic and genome-wide genotypic data are available for over 60,000 children, in addition to genome-wide genotypes for over 20,000 mothers and epigenome-wide data for over 6,000 children. Combined with the enormous progress in methodology, the results of the research performed in this network will greatly expand our knowledge regarding the etiology of mental health symptoms in children and adolescents and shed light on possible targets for prevention and intervention, e.g. by drug target validation. Moreover, it will provide Early Stage Researchers (ESRs) with an excellent training in the psychiatric genomics field given by a multidisciplinary team of eminent scientists from the academic and non-academic sector highly experienced in e.g., gene-environment interaction and covariation analyses, (epi)genome-wide association studies, Mendelian Randomization (MR) and polygenic analyses.

With a focus on common and debilitating problems in childhood and adolescence, including depression, anxiety and Attention Deficit Hyperactivity Disorder, CAPICE will contribute to improving later outcomes of young people in European countries with child and adolescent psychopathology.

Source : CAPICE website

General Info on genetics and psychopathology

Risk factors for psychopathology – Nature or Nurture?
24 September 2019

I started studying clinical psychology with a vision to reduce the burden of mental ill-health. The most logical way to accomplish this was to investigate factors that may lead to the development of mental health problems as early in life as possible. Therefore, I began to investigate the effect of problematic parent-interactions on children’s mental health. I spent hours and hours observing video material of parents affected by depression interacting with their young children. 

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The role of genes in the development of mental health problemsRisk factors for psychopathology – Nature or Nurture?
16 September 2019

It is highly probable that an individual living with a psychiatric disorder such as anxiety or depression has a family member that also has mental health problems. Similar to traits like height and eye color, psychiatric problems are also heritable. This is why health practitioners often ask for the family history of mental illness when making a diagnosis.
Research suggests that psychiatric disorders are strongly influenced by genetic factors. In the past, studies in twins were the most popular method of investigating the genetic basis of psychiatric traits.

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